POLR3C Gene Summary [Human]
Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | POLR3C |
| Official Name | RNA polymerase III subunit C [Source:HGNC Symbol;Acc:HGNC:30076] |
| Ensembl ID | ENSG00000186141 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit C |
| Synonyms | 4933407E01Rik, C82, LOC101060460, polymerase (RNA) III (DNA directed) polypeptide C, RNA polymerase III subunit C, RPC3, RPC62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- DNA-directed RNA polymerase
- enzyme
- protein binding
- RNA polymerase III subunit RPC82 helix-turn-helix domain
- RNA polymerase III subunit RPC82
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- transcription, DNA-dependent
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed RNA polymerase activity
- protein binding
- single-stranded DNA binding