ELAPOR1 Gene Summary [Human]
Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | ELAPOR1 |
| Official Name | endosome-lysosome associated apoptosis and autophagy regulator 1 [Source:HGNC Symbol;Acc:HGNC:29618] |
| Ensembl ID | ENSG00000116299 |
| Bio databases IDs | |
| Aliases | endosome-lysosome associated apoptosis and autophagy regulator 1, estrogen induced gene 121 |
| Synonyms | 5330417C22Rik, EIG121, endosome-lysosome associated apoptosis and autophagy regulator 1, Iir, Inceptor, Insulin inhibitory receptor, KIAA1324, RGD1310209 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELAPOR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tyrosine-protein kinase ephrin type A/B receptor-like
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- primary genetic hyperlipidemia
- teratozoospermia
- endometriosis
- oligozoospermia
regulates
- insulin
- glycogen
- IGF1R/INSR
role in cell
- growth
- proliferation
- migration
- morphology
- contact growth inhibition
- organization
- assembly
- area
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lysosome
- trans Golgi network
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELAPOR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of autophagic vacuole assembly
- cellular response to starvation
- positive regulation of vacuole organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- trans-Golgi network
- extracellular vesicular exosome
- late endosome
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- RNA binding