TAF1A Gene Summary [Human]
This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | TAF1A |
| Official Name | TATA-box binding protein associated factor, RNA polymerase I subunit A [Source:HGNC Symbol;Acc:HGNC:11532] |
| Ensembl ID | ENSG00000143498 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor, RNA polymerase I subunit A |
| Synonyms | MGC:17061, mTAFI48, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I, A, TATA-box binding protein associated factor, RNA polymerase I subunit A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- TAF RNA Polymerase I subunit A
Pathways
Biological processes and signaling networks where the TAF1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- RNA polymerase transcription factor SL1 complex
- microtubule cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding