CIP2A Gene Summary [Human]
Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CIP2A |
| Official Name | cellular inhibitor of PP2A [Source:HGNC Symbol;Acc:HGNC:29302] |
| Ensembl ID | ENSG00000163507 |
| Bio databases IDs | |
| Aliases | cellular inhibitor of PP2A, cancerous inhibitor of protein phosphatase 2A |
| Synonyms | C330027C09, C330027C09Rik, cell proliferation regulating inhibitor of protein phosphatase 2A, cellular inhibitor of PP2A, KIAA1524, NOCIVA, p90, RGD1310335 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIP2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuf2, DHR10-like domain
- Tropomyosin
- protein phosphatase inhibitor activity
- TPR/MLP1/MLP2-like protein
- Domain of unknown function (DUF4515)
- RNase Y N-terminal region
- Ezrin/radixin/moesin, alpha-helical domain
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- organismal death
- lung cancer
- colorectal cancer
- breast cancer
- tongue squamous cell carcinoma
- tongue squamous cell cancer
- colon cancer
- melanoma cancer
- basal-like breast cancer
role in cell
- quantity
- expression in
- apoptosis
- proliferation
- inhibition in
- phosphorylation in
- migration
- growth
- invasion by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
- chromosome
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIP2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome organization
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- chromosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- protein homodimerization activity
- cadherin binding