SRM
SRM Gene Summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | SRM |
| Official Name | spermidine synthase [Source:HGNC Symbol;Acc:HGNC:11296] |
| Ensembl ID | ENSG00000116649 |
| Bio databases IDs | |
| Aliases | spermidine synthase |
| Synonyms | LOC100912604,LOC689673,PAPT,SpdST,SPDSY,Spermidine synthase,SPS1,SRML1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Spermidine synthase tetramerization domain
- protein homodimerization
- spermidine synthase
- enzyme
- protein binding
- AdoMet_MTases
- identical protein binding
- Spermine/spermidine synthase domain
Pathways
Biological processes and signaling networks where the SRM gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ZRANB1
- IKBKE
- HDAC6
- AGR2
- COPS5
- PRKN
- TRIM67
- MOV10
- RPA2
- EFHC1
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- ulcerative colitis
- psoriasis
- epidermal hyperplasia
- delayed hypersensitive reaction
- Huntington disease
regulated by
- GLI1
- HTT
- estrogen
- LAMA4
- mibolerone
- severe acute respiratory syndrome coronavirus 2
- mifepristone
- UCP1
- ESR1
- IL4
regulates
- spermidine
- polyamines
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SRM gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- spermidine biosynthetic process
- polyamine metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- spermidine synthase activity
- identical protein binding
- protein binding
- protein homodimerization activity