TMEM9 Gene Summary [Human]
Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMEM9 |
| Official Name | transmembrane protein 9 [Source:HGNC Symbol;Acc:HGNC:18823] |
| Ensembl ID | ENSG00000116857 |
| Bio databases IDs | |
| Aliases | transmembrane protein 9 |
| Synonyms | 1500015G18Rik, DERM4, DERP4, DKFZP564I1216, HSPC186, TMEM9A, transmembrane protein 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TMEM9
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- endosomes
- lysosome
- cytoplasmic bridges
- lysosome membrane
- late endosomes
- multivesicular bodies
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosomal lumen acidification
- protein transport
- lysosomal lumen acidification
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of protein catabolic process
- proton-transporting V-type ATPase complex assembly
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- intercellular bridge
- mitotic spindle
- intracellular membrane-bounded organelle
- late endosome
- multivesicular body membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding