CD160 Gene Summary [Human]
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD160 |
| Official Name | CD160 molecule [Source:HGNC Symbol;Acc:HGNC:17013] |
| Ensembl ID | ENSG00000117281 |
| Bio databases IDs | |
| Aliases | CD160 molecule |
| Synonyms | BY55, CD160 antigen, CD160 molecule, LOC101060629, NK1, NK28, RGD1563598 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD160 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- kinase binding
- signaling receptor activity
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- receptor binding
- transmembrane receptor
- Immunoglobulin V-set domain
- MHC class I receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Huntington disease
- idiopathic pulmonary fibrosis
- breast carcinoma
- trigonocephaly
- intellectual disability and developmental delay
- chronic lymphocytic leukemia
- hairy cell leukemia
- global developmental delay with intellectual disability
- lepromatous leprosy
role in cell
- apoptosis
- cell death
- proliferation
- expression in
- co-stimulation
- cell cycle progression in
- secretion in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD160 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of CD4-positive, alpha beta T cell costimulation
- defense response to Gram-negative bacterium
- T cell costimulation
- adaptive immune response
- mucosal immune response
- positive regulation of natural killer cell mediated cytotoxicity
- protein kinase B signaling cascade
- negative regulation of T cell receptor signaling pathway
- angiogenesis
- positive regulation of natural killer cell mediated immune response to tumor cell
- innate immune response
- positive regulation of interferon-gamma production
- positive regulation of natural killer cell cytokine production
- positive regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- protein binding
- MHC class I receptor activity
- MHC class Ib receptor activity
- activating MHC class I receptor activity
- receptor binding
- kinase binding