Cd160 Gene Summary [Mouse]
Enables MHC class I protein complex binding activity. Involved in mucosal immune response; positive regulation of natural killer cell mediated immune response to tumor cell; and positive regulation of type II interferon production. Acts upstream of or within defense response to Gram-negative bacterium. Located in plasma membrane. Orthologous to human CD160 (CD160 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd160 |
| Official Name | CD160 antigen [Source:MGI Symbol;Acc:MGI:1860383] |
| Ensembl ID | ENSMUSG00000038304 |
| Bio databases IDs | |
| Aliases | CD160 antigen |
| Synonyms | BY55, CD160 antigen, CD160 molecule, LOC101060629, NK1, NK28, RGD1563598 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd160 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- kinase binding
- signaling receptor activity
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- receptor binding
- transmembrane receptor
- Immunoglobulin V-set domain
- MHC class I receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Huntington disease
- idiopathic pulmonary fibrosis
- breast carcinoma
- trigonocephaly
- intellectual disability and developmental delay
- chronic lymphocytic leukemia
- hairy cell leukemia
- global developmental delay with intellectual disability
- lepromatous leprosy
role in cell
- apoptosis
- cell death
- proliferation
- expression in
- co-stimulation
- cell cycle progression in
- secretion in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd160 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of CD4-positive, alpha beta T cell costimulation
- defense response to Gram-negative bacterium
- T cell costimulation
- adaptive immune response
- mucosal immune response
- positive regulation of natural killer cell mediated cytotoxicity
- protein kinase B signaling cascade
- negative regulation of T cell receptor signaling pathway
- angiogenesis
- positive regulation of natural killer cell mediated immune response to tumor cell
- innate immune response
- positive regulation of interferon-gamma production
- positive regulation of natural killer cell cytokine production
- positive regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- protein binding
- MHC class I receptor activity
- MHC class Ib receptor activity
- activating MHC class I receptor activity
- receptor binding
- kinase binding