TMED5 Gene Summary [Human]
Involved in Golgi ribbon formation. Located in cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMED5 |
| Official Name | transmembrane p24 trafficking protein 5 [Source:HGNC Symbol;Acc:HGNC:24251] |
| Ensembl ID | ENSG00000117500 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 5 |
| Synonyms | 3110020O18Rik, 4432412D15Rik, CGI-100, LRRG00120, p24g2, p24gamma2, p28, transmembrane p24 trafficking protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMED5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- emp24/gp25L/p24 family/GOLD
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMED5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- intracellular protein transport
- Golgi ribbon formation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- endoplasmic reticulum exit site
- ER to Golgi transport vesicle
- Golgi apparatus
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity