MREG Gene Summary [Human]
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MREG |
| Official Name | melanoregulin [Source:HGNC Symbol;Acc:HGNC:25478] |
| Ensembl ID | ENSG00000118242 |
| Bio databases IDs | |
| Aliases | melanoregulin |
| Synonyms | DSU, FLJ10116, Gm974, melanoregulin, RGD1562333, WDT2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MREG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanoregulin
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- Rett syndrome
- COVID-19
- carcinoma in situ
- epithelial cancer in situ
role in cell
- differentiation
- accumulation
- maturation
- localization
- degradation in
- transport
- degradation
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cellular membrane
- granules
- endosomal membrane
- perinuclear vesicles
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MREG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- minus-end-directed organelle transport along microtubule
- melanocyte differentiation
- melanosome localization
- phagosome maturation
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- late endosome membrane
- cytoplasmic vesicle membrane
- melanosome
- macromolecular complex
- organelle membrane
- apical plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding