CDC26 Gene Summary [Human]
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CDC26 |
| Official Name | cell division cycle 26 [Source:HGNC Symbol;Acc:HGNC:17839] |
| Ensembl ID | ENSG00000176386 |
| Bio databases IDs | |
| Aliases | cell division cycle 26, CDC26 subunit of anaphase promoting complex, anaphase promoting complex subunit 12 |
| Synonyms | 2010012C09Rik, ANAPC12, APC12, BWK-2, C9orf17, cell division cycle 26 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex APC subunit CDC26
- protein binding
Pathways
Biological processes and signaling networks where the CDC26 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding