Mreg Gene Summary [Mouse]
Enables phosphatidylinositol binding activity. Involved in melanosome localization; minus-end-directed organelle transport along microtubule; and phagosome maturation. Acts upstream of or within melanocyte differentiation and melanosome transport. Located in late endosome membrane and melanosome membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; inner ear; and liver. Orthologous to human MREG (melanoregulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mreg |
| Official Name | melanoregulin [Source:MGI Symbol;Acc:MGI:2151839] |
| Ensembl ID | ENSMUSG00000039395 |
| Bio databases IDs | |
| Aliases | melanoregulin |
| Synonyms | DSU, FLJ10116, Gm974, melanoregulin, RGD1562333, WDT2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mreg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanoregulin
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- Rett syndrome
- COVID-19
- carcinoma in situ
- epithelial cancer in situ
role in cell
- differentiation
- accumulation
- maturation
- localization
- degradation in
- transport
- degradation
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cellular membrane
- granules
- endosomal membrane
- perinuclear vesicles
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mreg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- minus-end-directed organelle transport along microtubule
- melanocyte differentiation
- melanosome localization
- phagosome maturation
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- late endosome membrane
- cytoplasmic vesicle membrane
- melanosome
- macromolecular complex
- organelle membrane
- apical plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding