NUDT21 Gene Summary [Human]
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NUDT21 |
| Official Name | nudix hydrolase 21 [Source:HGNC Symbol;Acc:HGNC:13870] |
| Ensembl ID | ENSG00000167005 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 21, cleavage factor Im complex 25 kDa subunit |
| Synonyms | 3110048P04Rik, 5730530J16RIK, AU014860, CFIM25, CPSF5, nudix hydrolase 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDT21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylation site
- mRNA 3' UTR binding
- mRNA binding
- protein homodimerization
- chromatin binding
- histone deacetylase binding
- protein binding
- identical protein binding
- NUDIX hydrolase superfamily
- RNA binding
Pathways
Biological processes and signaling networks where the NUDT21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic epithelial cancer
- pancreatic cancer
- bleomycin-induced pulmonary fibrosis
- systemic sclerosis
- metabolic syndrome X
- fibrotic disorder of skin
- organismal death
- seminoma
- germ cell cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- migration
- clonogenicity
- colony formation by
- shortening in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- Mitochondria
- spliceosomes
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDT21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of stem cell differentiation
- posttranscriptional regulation of gene expression
- protein tetramerization
- cell differentiation
- mRNA 3'-end processing
- mRNA processing
- positive regulation of pro-B cell differentiation
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nuclear body
- cytoplasm
- mRNA cleavage and polyadenylation specificity factor complex
- paraspeckles
- centriolar satellite
- mRNA cleavage factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- mRNA 3'-UTR AU-rich region binding
- mRNA binding
- chromatin binding