SLC16A7 Gene Summary [Human]
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | SLC16A7 |
| Official Name | solute carrier family 16 member 7 [Source:HGNC Symbol;Acc:HGNC:10928] |
| Ensembl ID | ENSG00000118596 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 member 7 |
| Synonyms | 4921534N07Rik, 9030411M13Rik, D630004K10Rik, Gm4150, MCT2, solute carrier family 16 member 7, solute carrier family 16 (monocarboxylic acid transporters), member 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC16A7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nitrite extrusion protein (nitrite facilitator)
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- monocarboxylic acid transporter
- pyruvate carrier
- monocarboxylate transporter 1
- identical protein binding
- symporter
- transporter
- lactate transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pigment dispersion syndrome
- Kawasaki disease
- colorectal cancer
- nonalcoholic fatty liver disease
- metastasis
- proximal tubular toxicity
- renal clear cell adenocarcinoma
- renal clear cell cancer
- glaucoma
- non-small cell lung carcinoma
regulates
- reactive oxygen species
- lactic acid
- methotrexate
- Collagen(s)
- monocarboxylic acid
- L-lactic acid
- pyruvic acid
- 4-hydroxybutanoic acid
- 3-iodothyronamine
role in cell
- excitability
- hydroxylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- perinuclear region
- cytosol
- synaptic membrane
- basolateral membrane
- nucleoplasm
- synapse
- axons
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC16A7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plasma membrane lactate transport
- lactate transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- symporter activity
- pyruvate secondary active transmembrane transporter activity
- lactate transmembrane transporter activity
- pyruvate transmembrane transporter activity