KTN1 Gene Summary [Human]

This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

Details

Type
Protein Coding
Official Symbol
KTN1
Official Name
kinectin 1 [Source:HGNC Symbol;Acc:HGNC:6467]
Ensembl ID
ENSG00000126777
Bio databases IDs NCBI: 3895 Ensembl: ENSG00000126777
Aliases kinectin 1
Synonyms CG1, KINECTIN, kinectin 1, KNT, Ktn, MU-RMS-40.19
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KTN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mitotic checkpoint protein
  • Crescentin protein
  • chromosome segregation protein SMC, primarily archaeal type
  • exonuclease SbcC
  • Synaptonemal complex protein 1 (SCP-1)
  • rad50
  • helix-rich Mycoplasma protein
  • protein binding
  • kinesin binding
  • FG repeat
  • Ribosome receptor lysine/proline rich region
  • chromosome segregation protein SMC, common bacterial type
  • RecF/RecN/SMC N terminal domain
  • RIM-binding protein of the cytomatrix active zone
  • Coiled-coil domain-containing protein 158
  • Rho-binding domain
  • transmembrane receptor

Pathways

Biological processes and signaling networks where the KTN1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • ischemic stroke
  • proliferative diabetic retinopathy
  • peripheral arterial disease
regulated by
regulates
role in cell
  • morphology
  • movement by
  • movement
  • disruption

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • membrane vesicles
  • polyribosome fractions
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • endoplasmic reticulum mitochondria contact site
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane
  • endoplasmic reticulum lumen
  • mitochondrial nucleoids
  • growth cone

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KTN1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein transport
  • microtubule-based movement

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • endoplasmic reticulum lumen
  • membrane
  • endoplasmic reticulum
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • cadherin binding
  • kinesin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.