RARRES1 Gene Summary [Human]
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RARRES1 |
| Official Name | retinoic acid receptor responder 1 [Source:HGNC Symbol;Acc:HGNC:9867] |
| Ensembl ID | ENSG00000118849 |
| Bio databases IDs | |
| Aliases | retinoic acid receptor responder 1, latexin-like |
| Synonyms | 5430417P09RIK, AI662122, LXNL, PERG-1, retinoic acid receptor responder 1, retinoic acid receptor responder (tazarotene induced) 1, TIG1, Tig1/retinoic acid receptor responder 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RARRES1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Latexin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- endometriosis
- asthma
- diabetic nephropathy
- cutaneous sarcoidosis
- non-Hodgkin disease
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
regulates
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- migration
- activation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RARRES1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metalloendopeptidase inhibitor activity