WIZ Gene Summary [Human]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WIZ |
| Official Name | WIZ zinc finger [Source:HGNC Symbol;Acc:HGNC:30917] |
| Ensembl ID | ENSG00000011451 |
| Bio databases IDs | |
| Aliases | WIZ zinc finger |
| Synonyms | widely-interspaced zinc finger motifs, WIZ zinc finger, ZNF803 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WIZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- binding protein
- double-stranded DNA binding
- nucleic acid binding
- enzyme binding
- transcription factor binding
- protein domain specific binding
- protein binding
- zinc finger domain
- sequence-specific DNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WIZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA replication involved in S phase
- protein stabilization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity