GRK5 Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRK5 |
| Official Name | G protein-coupled receptor kinase 5 [Source:HGNC Symbol;Acc:HGNC:4544] |
| Ensembl ID | ENSG00000198873 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 5 |
| Synonyms | FP2025, GPRK5, G protein-coupled receptor kinase, G protein-coupled receptor kinase 5, LOC100131848 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protein serine/threonine kinase
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- beta-adrenergic-receptor kinase
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Protein kinase domain
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
Pathways
Biological processes and signaling networks where the GRK5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- non-insulin-dependent diabetes mellitus
- hypothermia
- astrocytosis
- gastroesophageal reflux
- acute myeloid leukemia
- Rett syndrome
- cardiac hypertrophy
- venous thromboembolism
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- replication in
- phosphorylation in
- binding in
- growth
- internalization by
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- detergent-insoluble fractions
- membrane fraction
- Cytoplasm
- Nucleus
- cytosol
- nuclear envelope
- nuclear speckles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of cell proliferation
- protein autophosphorylation
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- fat cell differentiation
- regulation of G-protein coupled receptor protein signaling pathway
- protein phosphorylation
- regulation of signal transduction
- tachykinin receptor signaling pathway
- negative regulation of apoptotic process
- apoptotic process
- Wnt receptor signaling pathway
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- nuclear speck
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- ATP binding
- protein binding
- beta-adrenergic receptor kinase activity
- G-protein coupled receptor kinase activity
- protein kinase activity
- phospholipid binding
- protein serine/threonine kinase activity