SERBP1 Gene Summary [Human]
Enables SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERBP1 |
| Official Name | SERPINE1 mRNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17860] |
| Ensembl ID | ENSG00000142864 |
| Bio databases IDs | |
| Aliases | SERPINE1 mRNA binding protein 1 |
| Synonyms | 1200009K13RIK, 9330147J08Rik, CGI-55, CHD3IP, HABP4L, Hero45, PAI1 binding, PAI1 MRNA binding, PAI-RBP1, Rda288, SERPINE1 mRNA binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hyaluronan / mRNA binding family
- mRNA 3' UTR binding
- translation repressor
- ribosome binding
- protein binding
- zDHHC ankyrin repeat binding domain
- Intracellular hyaluronan-binding protein 4 N-terminal
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the SERBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- colon cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- infection by Influenza A virus subtype H1N1
regulates
- SERPINE1
- progesterone
role in cell
- binding
- apoptosis
- processing in
- translation in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- organelle
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- plasma membrane extracellular face
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA stability
- negative regulation of translation
- PML body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- non-membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- protein binding
- RNA binding
- cadherin binding
- ribosome binding
- translation repressor activity
- mRNA 3'-UTR binding