AREL1 Gene Summary [Human]
Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | AREL1 |
| Official Name | apoptosis resistant E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:20363] |
| Ensembl ID | ENSG00000119682 |
| Bio databases IDs | |
| Aliases | apoptosis resistant E3 ubiquitin protein ligase 1, fibrosis-inducing E3 ligase 1 |
| Synonyms | 1110018G07Rik, apoptosis resistant E3 ubiquitin protein ligase 1, FIEL1, KIAA0317, RGD1307597 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AREL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Filamin/ABP280 repeat
- HECTc
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AREL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- protein polyubiquitination
- negative regulation of apoptotic process
- apoptotic process
- regulation of inflammatory response
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding