Arel1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Involved in protein ubiquitination; regulation of inflammatory response; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Arel1 |
| Official Name | apoptosis resistant E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1915747] |
| Ensembl ID | ENSMUSG00000042350 |
| Bio databases IDs | |
| Aliases | apoptosis resistant E3 ubiquitin protein ligase 1 |
| Synonyms | 1110018G07Rik, apoptosis resistant E3 ubiquitin protein ligase 1, FIEL1, KIAA0317, RGD1307597 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Filamin/ABP280 repeat
- HECTc
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arel1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- protein polyubiquitination
- negative regulation of apoptotic process
- apoptotic process
- regulation of inflammatory response
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding