DENND10 Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Located in late endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DENND10 |
| Official Name | DENN domain containing 10 [Source:HGNC Symbol;Acc:HGNC:31793] |
| Ensembl ID | ENSG00000119979 |
| Bio databases IDs | |
| Aliases | DENN domain containing 10 |
| Synonyms | 1810055E12Rik, DENN domain containing 10, FAM45A, RGD1308326 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DENND10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DENND10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- endosome transport via multivesicular body sorting pathway
- regulation of early endosome to late endosome transport
Cellular Component
Where in the cell the gene product is active
- late endosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding