ADIPOR1 Gene Summary [Human]
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | ADIPOR1 |
| Official Name | adiponectin receptor 1 [Source:HGNC Symbol;Acc:HGNC:24040] |
| Ensembl ID | ENSG00000159346 |
| Bio databases IDs | |
| Aliases | adiponectin receptor 1 |
| Synonyms | 2810031L11RIK, ACDCR1, adiponectin receptor 1, CGI-45, PAQR1, TESBP1A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADIPOR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haemolysin-III related
- hormone binding
- signaling receptor activity
- protein kinase binding
- intracellular domain
- channel protein, hemolysin III family
- protein-hormone receptor
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ADIPOR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- insulin resistance
- hyperglycemia
- diabetic nephropathy
- impaired glucose tolerance
- weight gain
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- migration
- activation in
- cell viability
- quantity
- growth
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADIPOR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin receptor signaling pathway
- leptin-mediated signaling pathway
- negative regulation of JAK-STAT cascade
- positive regulation of JAK-STAT cascade
- hormone-mediated signaling pathway
- negative regulation of epithelial to mesenchymal transition
- regulation of glucose metabolic process
- fatty acid oxidation
- negative regulation of cell growth
- glucose homeostasis
- negative regulation of epithelial cell migration
- adiponectin-mediated signaling pathway
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- adipokinetic hormone receptor activity
- identical protein binding
- protein binding
- metal ion binding
- adiponectin binding
- signaling receptor activity