SEC16B Gene Summary [Human]
SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]
Details
| Type | Processed Transcript |
| Official Symbol | SEC16B |
| Official Name | SEC16 homolog B, endoplasmic reticulum export factor [Source:HGNC Symbol;Acc:HGNC:30301] |
| Ensembl ID | ENSG00000120341 |
| Bio databases IDs | |
| Aliases | SEC16 homolog B, endoplasmic reticulum export factor, regucalcin gene promotor region related protein |
| Synonyms | LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16 homolog B, endoplasmic reticulum export factor, SEC16S |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC16B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC16B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peroxisome fission
- ER to Golgi vesicle-mediated transport
- positive regulation of gene expression
- Golgi organization
- autophagy
- protein transport
- peroxisome organization
- protein localization to endoplasmic reticulum exit site
- positive regulation of protein exit from endoplasmic reticulum
- endoplasmic reticulum organization
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum exit site
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding