EXOSC8 Gene Summary [Human]
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
Details
| Type | Processed Transcript |
| Official Symbol | EXOSC8 |
| Official Name | exosome component 8 [Source:HGNC Symbol;Acc:HGNC:17035] |
| Ensembl ID | ENSG00000120699 |
| Bio databases IDs | |
| Aliases | exosome component 8, CBP-interacting protein 3, Opa interacting protein 2 |
| Synonyms | 2310032N20Rik, bA421P11.3, CIP3, EAP2, Exosome component 8, mKIAA4013, OIP2, p9, PCH1C, RRP43, Rrp43p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOSC8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3' exoribonuclease family, domain 2
- RNase PH-like 3'-5' exoribonucleases
- mRNA 3' UTR binding
- enzyme
- protein binding
- identical protein binding
- 3' exoribonuclease family, domain 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal carcinoma
- colorectal carcinomagenesis
- gastric adenocarcinoma
- epithelial neoplasia
- colorectal cancer
- pontocerebellar hypoplasia type 1C
- hereditary spastic ataxia
- epithelial cancer
- abdominal cancer
role in cell
- growth
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXOSC8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear polyadenylation-dependent rRNA catabolic process
- U4 snRNA 3'-end processing
- U1 snRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process
- nuclear mRNA surveillance
- RNA processing
- nuclear polyadenylation-dependent tRNA catabolic process
- U5 snRNA 3'-end processing
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- RNA catabolic process
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nuclear exosome (RNase complex)
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- chromosome
- nucleolus
- fibrillar center
- nucleoplasm
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- exoribonuclease activity