Hcrtr1 Gene Summary [Mouse]
Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcrtr1 |
| Official Name | hypocretin (orexin) receptor 1 [Source:MGI Symbol;Acc:MGI:2385650] |
| Ensembl ID | ENSMUSG00000028778 |
| Bio databases IDs | |
| Aliases | hypocretin (orexin) receptor 1 |
| Synonyms | Hctr1, hypocretin (orexin) receptor 1, hypocretin receptor 1, ORXR1, OX1R, OXR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hcrtr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- orexin receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- immunoreceptor tyrosine switch motif
Pathways
Biological processes and signaling networks where the Hcrtr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- depressive disorder
- binge drinking
- post-traumatic stress disorder
- shift work sleep disorder
- behavioral arrest
- insomnia
- advanced solid tumor
- bipolar I disorder
- idiopathic inflammatory myopathy
role in cell
- apoptosis
- excitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hcrtr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- cytosolic calcium ion homeostasis
- feeding behavior
- synaptic transmission
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- peptide hormone binding
- peptide binding
- orexin receptor activity