SLITRK3 Gene Summary [Human]
This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | SLITRK3 |
| Official Name | SLIT and NTRK like family member 3 [Source:HGNC Symbol;Acc:HGNC:23501] |
| Ensembl ID | ENSG00000121871 |
| Bio databases IDs | |
| Aliases | SLIT and NTRK like family member 3 |
| Synonyms | SLIT and NTRK like family member 3, SLIT and NTRK-like family, member 3, ST3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLITRK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLITRK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- terminal button organization
- axonogenesis
- gephyrin clustering
- neurotransmitter-gated ion channel clustering
- positive regulation of synapse assembly
- synaptic transmission, GABAergic
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding