PRKCD Gene Summary [Human]
The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | PRKCD |
| Official Name | protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399] |
| Ensembl ID | ENSG00000163932 |
| Bio databases IDs | |
| Aliases | protein kinase C delta |
| Synonyms | ALPS3, Ca+-independent PKC, CVID9, D14Ertd420e, MAY1, novel Pkc delta, novel Pkc δ, nPKC-delta, nPKC-δ, PKCD, PKC[d], PKC delta, PKC δ, protein kinase C delta, protein kinase C, delta, protein kinase C δ, protein kinase C, δ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKCD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- C1A domain
- Protein kinase domain
- enzyme activator activity
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- alcohol group acceptor phosphotransferase
- protein kinase C
- Tyrosine kinase, catalytic domain
- cysteine rich domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- nuclear localization sequence
- enzyme binding
- calcium independent protein kinase C
- protein domain specific binding
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- pseudosubstrate domain
- C1B domain
- sXXN motif
- hydrophobic domain
Pathways
Biological processes and signaling networks where the PRKCD gene in human plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- ErbB4 Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Gαq Signaling
- Hepatic Cholestasis
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- benign neoplasia
- metastasis
- pain
- cancer
- neoplasia
- proteinuria
- prostate cancer
- epithelial cancer
role in cell
- cellular infiltration by
- expression in
- production in
- proliferation
- synthesis in
- quantity
- activation
- apoptosis
- activation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- membrane fraction
- detergent resistant lipid raft fraction
- azurophil granule lumen
- cytoskeleton
- cilia
- perinuclear membrane
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- basal bodies
- vesicles
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- intercellular junctions
- granules
- cytosol
- caveolae
- trans Golgi network
- nucleoplasm
- perinuclear space
- nuclear envelope
- nuclear matrix
- neurites
- cytoplasmic vesicles
- endolysosomes
- cellular protrusions
- perikaryon
- dendrites
- dendritic knobs
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKCD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- negative regulation of MAP kinase activity
- negative regulation of platelet aggregation
- cellular senescence
- negative regulation of glial cell apoptotic process
- regulation of mRNA stability
- Fc-gamma receptor signaling pathway involved in phagocytosis
- negative regulation of filopodium assembly
- protein phosphorylation
- negative regulation of protein binding
- post-translational protein modification
- cell chemotaxis
- termination of signal transduction
- apoptotic process
- cellular response to UV
- activation of protein kinase activity
- positive regulation of glucosylceramide catabolic process
- positive regulation of sphingomyelin catabolic process
- cellular response to hydrogen peroxide
- intracellular signal transduction
- negative regulation of peptidyl-tyrosine phosphorylation
- positive regulation of protein import into nucleus
- positive regulation of phospholipid scramblase activity
- signal transduction
- negative regulation of inflammatory response
- B cell proliferation
- induction of apoptosis by oxidative stress
- response to DNA damage stimulus
- defense response to bacterium
- negative regulation of insulin receptor signaling pathway
- regulation of actin cytoskeleton organization
- negative regulation of actin filament polymerization
- immunoglobulin mediated immune response
- cellular response to hydroperoxide
- positive regulation of protein dephosphorylation
- regulation of receptor activity
- positive regulation of endodeoxyribonuclease activity
- positive regulation of ceramide biosynthetic process
- peptidyl-serine phosphorylation
- protein stabilization
- regulation of ceramide biosynthetic process
- peptidyl-threonine phosphorylation
- positive regulation of apoptotic signaling pathway
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- extracellular region
- plasma membrane
- nucleoplasm
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytosol
- nuclear matrix
- azurophil granule lumen
- endolysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- enzyme activator activity
- protein kinase activity
- protein serine/threonine kinase activity
- protein kinase C activity
- ATP binding
- calcium-independent protein kinase C activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- insulin receptor substrate binding
- enzyme binding