HOXB13 Gene Summary [Human]
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HOXB13 |
| Official Name | homeobox B13 [Source:HGNC Symbol;Acc:HGNC:5112] |
| Ensembl ID | ENSG00000159184 |
| Bio databases IDs | |
| Aliases | homeobox B13 |
| Synonyms | homeo box B13, HPC9, PSGD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOXB13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- methyl-CpG binding
- Hox protein A13 N terminal
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- neoplasia
- epithelial cancer
- cancer
- epithelial neoplasia
- metastasis
- prostate cancer
- pancreatic cancer
- prostatic carcinoma
- prostatic adenocarcinoma
role in cell
- expression in
- proliferation
- apoptosis
- growth
- differentiation
- signaling in
- formation
- invasion by
- G1 phase
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOXB13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- angiogenesis
- epidermis development
- response to wounding
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- response to testosterone stimulus
- regulation of growth
- epithelial cell maturation involved in prostate gland development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity