GPSM2 Gene Summary [Human]
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | GPSM2 |
| Official Name | G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29501] |
| Ensembl ID | ENSG00000121957 |
| Bio databases IDs | |
| Aliases | G protein signaling modulator 2 |
| Synonyms | 6230410J09Rik, CMCS, DFNB82, G-protein signaling modulator 2, G-protein signalling modulator 2 (AGS3-like, C. elegans), LGN, mPins, PINS, RGD1560967 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPSM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- TPR repeat
- binding protein
- GDP-dissociation inhibitor
- Tetratricopeptide repeats
- GoLoco motif
- protein domain specific binding
- protein binding
- tetratricopeptide repeat
- identical protein binding
- Numa binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- hereditary disorder
- autosomal recessive deafness type 82
- autosomal recessive deafness
- absent pinna reflex
- hearing loss
- susceptibility to familial breast-ovarian cancer type 2
- GPSM2-related disorder
- colon cancer
role in cell
- differentiation
- quantity
- segregation
- formation
- organization
- abnormal morphology
- assembly
- orientation in
- orientation
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- perinuclear region
- cell cortex
- centrosome
- centriole
- midbody
- cytosol
- perinuclear space
- spindle pole
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPSM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- establishment of mitotic spindle orientation
- G-protein coupled receptor signaling pathway
- maintenance of centrosome location
- mitotic spindle organization
- regulation of mitotic spindle organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- lateral plasma membrane
- cytoplasm
- cell cortex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein domain specific binding
- identical protein binding
- protein binding
- GDP-dissociation inhibitor activity
- G-protein alpha-subunit binding
- dynein complex binding