TIA1 Gene Summary [Human]
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | TIA1 |
| Official Name | TIA1 cytotoxic granule associated RNA binding protein [Source:HGNC Symbol;Acc:HGNC:11802] |
| Ensembl ID | ENSG00000116001 |
| Bio databases IDs | |
| Aliases | TIA1 cytotoxic granule associated RNA binding protein, T-cell-restricted intracellular antigen-1, nucleolysin TIA-1 isoform p40 |
| Synonyms | 2310050N03Rik, ALS26, cytotoxic granule-associated RNA binding protein 1, mTIA-1, TIA1 cytotoxic granule-associated RNA binding protein, WDM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- poly(A) binding protein
- protein binding
- PR domain
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- hepatic fibrosis
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- arthritis
- growth failure
- mature T-cell neoplasia
role in cell
- cell death
- expression in
- apoptosis
- migration
- generation in
- proliferation
- binding in
- formation
- binding
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein granule
- Cytoplasm
- granules
- cytoplasmic aggregates
- cytosol
- nucleoplasm
- cytotoxic granule
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- apoptotic process
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- negative regulation of cytokine production
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear stress granule
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- poly(A) RNA binding
- mRNA 3'-UTR binding