Gpsm2 Gene Summary [Rat]
Predicted to enable several functions, including G-protein alpha-subunit binding activity; dynein complex binding activity; and identical protein binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpsm2 |
| Official Name | G-protein signaling modulator 2 [Source:RGD Symbol;Acc:1560967] |
| Ensembl ID | ENSRNOG00000012149 |
| Bio databases IDs | |
| Aliases | G-protein signaling modulator 2 |
| Synonyms | 6230410J09Rik, CMCS, DFNB82, G-protein signaling modulator 2, G-protein signalling modulator 2 (AGS3-like, C. elegans), LGN, mPins, PINS, RGD1560967 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpsm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- TPR repeat
- binding protein
- GDP-dissociation inhibitor
- Tetratricopeptide repeats
- GoLoco motif
- protein domain specific binding
- protein binding
- tetratricopeptide repeat
- identical protein binding
- Numa binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- hereditary disorder
- autosomal recessive deafness type 82
- autosomal recessive deafness
- absent pinna reflex
- hearing loss
- susceptibility to familial breast-ovarian cancer type 2
- GPSM2-related disorder
- colon cancer
role in cell
- differentiation
- quantity
- segregation
- formation
- organization
- abnormal morphology
- assembly
- orientation in
- orientation
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- perinuclear region
- cell cortex
- centrosome
- centriole
- midbody
- cytosol
- perinuclear space
- spindle pole
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpsm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- establishment of mitotic spindle orientation
- G-protein coupled receptor signaling pathway
- maintenance of centrosome location
- mitotic spindle organization
- regulation of mitotic spindle organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- lateral plasma membrane
- cytoplasm
- cell cortex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein domain specific binding
- identical protein binding
- protein binding
- GDP-dissociation inhibitor activity
- G-protein alpha-subunit binding
- dynein complex binding