ARL4A Gene Summary [Human]
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARL4A |
| Official Name | ADP ribosylation factor like GTPase 4A [Source:HGNC Symbol;Acc:HGNC:695] |
| Ensembl ID | ENSG00000122644 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 4A |
| Synonyms | ADP-ribosylation factor-like 4A, ARF like GTPase 4A, ARL4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- cytosol
- microsome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity