GCC2 Gene Summary [Human]
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | GCC2 |
| Official Name | GRIP and coiled-coil domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23218] |
| Ensembl ID | ENSG00000135968 |
| Bio databases IDs | |
| Aliases | GRIP and coiled-coil domain containing 2 |
| Synonyms | 0610043A03RIK, 2210420P05Rik, 2600014C01RIK, AC170751.4, GCC185, GRIP and coiled-coil domain containing 2, mKIAA0336, RANBP2L4, REN53 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- GRIP domain
- enzyme binding
- helix-rich Mycoplasma protein
- protein binding
- identical protein binding
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- Rab binding domain
- golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
- trans Golgi network
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule anchoring
- protein localization in Golgi apparatus
- Golgi to plasma membrane protein transport
- late endosome to Golgi transport
- regulation of protein exit from endoplasmic reticulum
- microtubule organizing center organization
- retrograde transport, endosome to Golgi
- protein targeting to lysosome
- Golgi ribbon formation
- recycling endosome to Golgi transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- small GTPase binding