CCDC57 Gene Summary [Human]
Involved in several processes, including G2/M transition of mitotic cell cycle; cilium assembly; and microtubule cytoskeleton organization. Located in centriolar satellite; centriole; and spindle microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CCDC57 |
| Official Name | coiled-coil domain containing 57 [Source:HGNC Symbol;Acc:HGNC:27564] |
| Ensembl ID | ENSG00000176155 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 57 |
| Synonyms | 4933434G05Rik, coiled-coil domain containing 57, FLJ23754, LOC108352168 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCDC57 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, common bacterial type
- chromosome segregation protein SMC, primarily archaeal type
- Rabaptin-like protein
- exonuclease SbcC
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- protein binding
- Spindle pole body component BBP1, C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- centrosome
- centriole
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCDC57 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G2/M transition of mitotic cell cycle
- cilium morphogenesis
- centriole replication
- microtubule nucleation
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- centrosome
- centriole
- cytoplasm
- centriolar satellite
Molecular Function
What the gene product does at the molecular level
- protein binding