USP45 Gene Summary [Human]
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | USP45 |
| Official Name | ubiquitin specific peptidase 45 [Source:HGNC Symbol;Acc:HGNC:20080] |
| Ensembl ID | ENSG00000123552 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 45 |
| Synonyms | 3110003C05Rik, 4930550B20RIK, GCAP7, LCA19, ubiquitin specific peptidase 45, ubiquitin specific petidase 45 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP45 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- DNA repair
- photoreceptor cell maintenance
- neural retina development
- proteolysis
- global genome nucleotide-excision repair
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- photoreceptor inner segment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding