PPP5C Gene Summary [Human]
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | PPP5C |
| Official Name | protein phosphatase 5 catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9322] |
| Ensembl ID | ENSG00000011485 |
| Bio databases IDs | |
| Aliases | protein phosphatase 5 catalytic subunit |
| Synonyms | ANP receptor protein kinase, P5/PPT, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit, protein phosphatase 5, catalytic subunit, Protein Phosphatase T, Protein phosphatase v-c, SERINE THREONINE protein PHOSPHATASE 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP5C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Hsp70 protein binding
- protein kinase binding
- ADP binding
- catalytic domain
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- ATP binding
- heat shock protein binding
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
- phosphatase domain
- identical protein binding
- RNA binding
- Calcineurin-like phosphoesterase
- microtubule binding
- protein serine/threonine kinase inhibitor
- binding protein
- protein phosphatase
- Tetratricopeptide repeats
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
- PPP5 TPR repeat region
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mouth mucosal ulcer
- chronic lymphocytic leukemia
- neuroticism
- infection by vesicular stomatitis virus
role in cell
- apoptosis
- expression in
- proliferation
- growth
- cell death
- size
- phosphorylation in
- activation in
- adhesion
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- microtubules
- cytosol
- nucleoplasm
- dendrite initial segments
- fibrils
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP5C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- peptidyl-serine dephosphorylation
- peptidyl-threonine dephosphorylation
- transcription, DNA-dependent
- protein dephosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to morphine
- response to lead ion
- mitotic cell cycle
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- lipid binding
- ADP binding
- protein serine/threonine phosphatase activity
- ATP binding
- phosphoprotein phosphatase activity
- RNA binding
- protein binding
- metal ion binding
- tau protein binding
- phosphatase activity
- Hsp90 protein binding
- myosin phosphatase activity