TNKS1BP1 Gene Summary [Human]
Enables ankyrin repeat binding activity and enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TNKS1BP1 |
| Official Name | tankyrase 1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:19081] |
| Ensembl ID | ENSG00000149115 |
| Bio databases IDs | |
| Aliases | tankyrase 1 binding protein 1 |
| Synonyms | CNOT12, mKIAA1741, TAB182, tankyrase 1 binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNKS1BP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- binding protein
- tankyrase binding domain
- enzyme binding
- protein domain specific binding
- protein binding
- Tankyrase binding protein C terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- hypertrophic cardiomyopathy
role in cell
- expression in
- binding in
- migration
- proliferation
- olaparib resistance
- cisplatin resistance
- invasion by
- response by
- phosphorylation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- Plasma Membrane
- cytosol
- cell-cell adherens junctions
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNKS1BP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein autophosphorylation
- cellular response to ionizing radiation
- telomere maintenance via telomerase
- positive regulation of peptidyl-threonine phosphorylation
- nuclear-transcribed mRNA poly(A) tail shortening
- double-strand break repair
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- adherens junction
- cytoskeleton
- cytoplasm
- cytosol
- CCR4-NOT complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- ankyrin repeat binding
- enzyme binding