POLR2G Gene Summary [Human]
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | POLR2G |
| Official Name | RNA polymerase II subunit G [Source:HGNC Symbol;Acc:HGNC:9194] |
| Ensembl ID | ENSG00000168002 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit G |
| Synonyms | 2410046K11Rik, A230108L04Rik, hRPB19, hsRPB7, polymerase (RNA) II (DNA directed) polypeptide G, RBP7, RNA polymerase II subunit G, RPB19, RPB7, RPO2-7L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein S1-like RNA-binding domain
- S1_like
- DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form
- DNA-directed RNA polymerase
- S1 RNA binding domain
- enzyme
- protein binding
- RNAP_Rpb7_N_like
Pathways
Biological processes and signaling networks where the POLR2G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- endoplasmic reticulum fraction
- Cytoplasm
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- nuclear-transcribed mRNA catabolic process
- transcription from RNA polymerase II promoter
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic mRNA processing body
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- single-stranded RNA binding
- translation initiation factor binding
- single-stranded DNA binding