NOP53 Gene Summary [Human]
Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NOP53 |
| Official Name | NOP53 ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:4333] |
| Ensembl ID | ENSG00000105373 |
| Bio databases IDs | |
| Aliases | NOP53 ribosome biogenesis factor |
| Synonyms | 5330430H08Rik, 9430097C02Rik, AU041936, D1Mgi9, GLTSCR2, NOP53 ribosome biogenesis factor, PICT-1, R74911 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOP53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nop53 (60S ribosomal biogenesis)
- 5S rRNA binding
- p53 binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- retinoblastoma
- retinoblastoma formation
- glioma
- glioma formation
- germ cell cancer
- skin cancer
- primitive neuroectodermal neoplasm
- flu
role in cell
- growth
- accumulation in
- binding in
- apoptosis
- cell cycle progression
- DNA damage response
- cell survival
- response by
- processing in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- heterochromatin
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOP53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- regulation of RIG-I signaling pathway
- regulation of apoptotic process
- rRNA processing
- ribosomal large subunit assembly
- response to DNA damage stimulus
- negative regulation of transcription from RNA polymerase II promoter
- regulation of protein phosphorylation
- negative regulation of protein complex assembly
- cellular response to hypoxia
- regulation of cell cycle
- protein stabilization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- rDNA heterochromatin
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- identical protein binding
- protein binding
- RNA binding
- 5S rRNA binding