NRK Gene Summary [Human]
The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | NRK |
| Official Name | Nik related kinase [Source:HGNC Symbol;Acc:HGNC:25391] |
| Ensembl ID | ENSG00000123572 |
| Bio databases IDs | |
| Aliases | Nik related kinase |
| Synonyms | AA407323, AA409510, AW538185, NESK, Nik related kinase, RGD1566163 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NRK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NRK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity
- protein serine/threonine kinase activity