Nrk Gene Summary [Mouse]
Enables protein kinase activity. Acts upstream of or within several processes, including parturition; positive regulation of JNK cascade; and regulation of spongiotrophoblast cell proliferation. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculature; and telencephalon. Orthologous to human NRK (Nik related kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrk |
| Official Name | Nik related kinase [Source:MGI Symbol;Acc:MGI:1351326] |
| Ensembl ID | ENSMUSG00000052854 |
| Bio databases IDs | |
| Aliases | Nik related kinase |
| Synonyms | AA407323, AA409510, AW538185, NESK, Nik related kinase, RGD1566163 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity
- protein serine/threonine kinase activity