MPHOSPH10 Gene Summary [Human]
This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | MPHOSPH10 |
| Official Name | M-phase phosphoprotein 10 [Source:HGNC Symbol;Acc:HGNC:7213] |
| Ensembl ID | ENSG00000124383 |
| Bio databases IDs | |
| Aliases | M-phase phosphoprotein 10, protein phosphatase 1, regulatory subunit 106, U3 small nucleolar ribonucleoprotein |
| Synonyms | 2810453H10RIK, 5730405D16Rik, CT90, M-phase phosphoprotein 10, M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein), MPP10, MPP10P, PPP1R106 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPHOSPH10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mpp10 protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPHOSPH10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- maturation of SSU-rRNA
- ribosomal small subunit biogenesis
- RNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- Mpp10 complex
- chromosome
- nucleolus
- small nucleolar ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding