TRAIP Gene Summary [Human]
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRAIP |
| Official Name | TRAF interacting protein [Source:HGNC Symbol;Acc:HGNC:30764] |
| Ensembl ID | ENSG00000183763 |
| Bio databases IDs | |
| Aliases | TRAF interacting protein, ring finger protein 206 |
| Synonyms | RNF206, SCKL9, TRAF-interacting protein, TRAFIP, TRIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- leucine zipper domain
- coiled-coil domain
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- RING-like zinc finger
- PCNA-interacting protein box
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- coronary artery disease
- growth failure
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- HER2 negative hormone receptor negative breast cancer
- chromosomal instability
- breast carcinoma
role in cell
- growth
- proliferation
- expression in
- invasion by
- migration
- upregulation in
- activation in
- production in
- phosphorylation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- nucleoplasm
- perinuclear space
- nucleoli
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of tumor necrosis factor-mediated signaling pathway
- apoptotic process
- replication fork processing
- response to DNA damage stimulus
- negative regulation of interferon-beta production
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- metal ion binding