TBCC Gene Summary [Human]
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TBCC |
| Official Name | tubulin folding cofactor C [Source:HGNC Symbol;Acc:HGNC:11580] |
| Ensembl ID | ENSG00000124659 |
| Bio databases IDs | |
| Aliases | tubulin folding cofactor C |
| Synonyms | 2810055C19Rik, CFC, tubulin folding cofactor C, tubulin-specific chaperone C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBCC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin-specific chaperone C N-terminal domain
- GTPase
- Tubulin binding cofactor C
- enzyme
- protein binding
- chaperone binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Endoplasmic Reticulum
- microtubules
- cytosol
- connecting cilia
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBCC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- post-chaperonin tubulin folding pathway
- protein folding
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- cytoskeleton
- cytoplasm
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- GTPase activity
- chaperone binding