CERS2 Gene Summary [Human]
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | CERS2 |
| Official Name | ceramide synthase 2 [Source:HGNC Symbol;Acc:HGNC:14076] |
| Ensembl ID | ENSG00000143418 |
| Bio databases IDs | |
| Aliases | ceramide synthase 2 |
| Synonyms | 0610013I17RIK, ceramide synthase 2, L3, LASS2, SP260, TMSG1, TRH3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CERS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- transcription regulator
- sphingosine N-acyltransferase
- N-acyltransferase
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- prostate cancer
- impaired glucose tolerance
- metastasis
- astrocytosis
- prostatic carcinoma
- cutaneous melanoma
- cutaneous melanoma cancer
role in cell
- proliferation
- migration
- cell death
- expression in
- phosphorylation in
- apoptosis
- synthesis in
- quantity
- degeneration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fimbria
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CERS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of axon regeneration
- ceramide biosynthetic process
- negative regulation of Schwann cell migration
- response to immobilization stress
- regulation of lipid metabolic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sphingosine N-acyltransferase activity