MT1M Gene Summary [Human]

This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]

Details

Type
Protein Coding
Official Symbol
MT1M
Official Name
metallothionein 1M [Source:HGNC Symbol;Acc:HGNC:14296]
Ensembl ID
ENSG00000205364
Bio databases IDs NCBI: 4499 Ensembl: ENSG00000205364
Aliases metallothionein 1M
Synonyms metallothionein 1M, MT1, MT1K, MT-IM
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MT1M often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • zinc ion binding
  • Metallothionein
  • protein binding

Pathways

Biological processes and signaling networks where the MT1M gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • breast cancer
  • hepatocellular carcinoma
  • epithelial cancer
  • gastric adenocarcinoma
  • coronary stenosis
  • endometriosis
  • abdominal aortic aneurysm
  • Huntington disease
  • chronic obstructive pulmonary disease
  • liver cancer
regulated by
  • dexamethasone
  • IFNG
  • IFNA2
  • ponesimod
  • TNF
  • Marburg virus
  • triamcinolone acetonide
  • NKX2-3
  • Streptococcus pneumoniae TIGR4
  • RAF1

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MT1M gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of growth
  • detoxification of copper ion
  • cellular response to zinc ion
  • cellular response to cadmium ion
  • cellular zinc ion homeostasis
  • cellular response to copper ion

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • zinc ion binding
  • protein binding
  • metal ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.