GFRA4 Gene Summary [Human]
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GFRA4 |
| Official Name | GDNF family receptor alpha 4 [Source:HGNC Symbol;Acc:HGNC:13821] |
| Ensembl ID | ENSG00000125861 |
| Bio databases IDs | |
| Aliases | GDNF family receptor alpha 4, persephin receptor |
| Synonyms | G630015H18RIK, GDNF family receptor alpha 4, GDNF family receptor α 4, glial cell line derived neurotrophic factor family receptor alpha 4, glial cell line derived neurotrophic factor family receptor α 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GFRA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glial cell line-derived neurotrophic factor receptor
- transmembrane receptor
- GDNF/GAS1 domain
- coreceptor
Pathways
Biological processes and signaling networks where the GFRA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GFRA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glial cell-derived neurotrophic factor receptor signaling pathway
- ossification
- nervous system development
- negative regulation of ossification
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glial cell-derived neurotrophic factor receptor activity