NCLN Gene Summary [Human]
Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NCLN |
| Official Name | nicalin [Source:HGNC Symbol;Acc:HGNC:26923] |
| Ensembl ID | ENSG00000125912 |
| Bio databases IDs | |
| Aliases | nicalin, nicastrin-like protein |
| Synonyms | 3100002P13RIK, LOC56926, NET59, NICALIN, RGD1309355 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- peptidase
- ribosome binding
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCLN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of left/right asymmetry in lateral mesoderm
- regulation of protein complex assembly
- protein stabilization
- regulation of signal transduction
- negative regulation of nodal signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding