PCID2 Gene Summary [Human]
This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | PCID2 |
| Official Name | PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653] |
| Ensembl ID | ENSG00000126226 |
| Bio databases IDs | |
| Aliases | PCI domain containing 2 |
| Synonyms | A730042J05Rik, F10, FLJ11305, LOC100129834, LOC105370376, PCI domain containing 2, RGD1307041 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCID2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- interchromatin granule cluster fractions
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCID2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- protein transport
- spleen development
- regulation of mRNA stability
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
- positive regulation of B cell differentiation
- negative regulation of transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcription export complex 2
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- double-stranded DNA binding